Hoffmann La-Roche

Fine chemical companies are generally either small and privately held or divisions of larger companies, such as Eastman Fine Chemicals (United States) and Lonza (Switzerland). Examples of large public fife science companies, which market fine chemicals as a subsidiary activity to their production for captive use, are Hoffmann-La Roche, Sandoz, and Boehringer Ingelheim, which produce and market bulk vitamins and liquid crystal intermediates, dyestuff intermediates, and bulk active ingredients, respectively. Table 3 fists some representative companies having an important fine chemical business. 

Eastman Chemical Eastman Chemical, Henkel Corp., Hoffmann-La Roche Eastman Chemical, UOP Pfi2er... 

Universal Foods (Wamer-Jenkinson, McCormick/Stange, Kohnstamn), Haarmann Reimer, Hoffmann-La Roche, Colorcon, Quest/Biocon... 

It can be estimated that approximately 3,000,000,000 of vitamins were sold in 1996. Market growth is slightly higher than population growth, but varies widely by individual vitamin, geographical area, and/or appHcation. The largest vitamin manufacturer is Hoffmann-La Roche. Other significant producers include BASE, Takeda, Eisai, and Rhc ne-Poulenc. Additional vitamins are produced in China, Russia and India. 

Vitamins Tasks F. Hoffmann-La Roche, Ltd., Basel, Swit2edand, 1994, p. i. 

V. Singh, personal communication, Hoffmann-La Roche Inc., Nutley, N.J., 1996. 

The biotin market is divided between agricultural and human use, with —90% of biotin used in the animal health care market and —10% for the human nutritional market. The major producers of biotin are Hoffmann-La Roche, Lon2a, E. Merck-Darmstadt, Rhc ne-Poulenc, Sumitomo Pharmaceutical, E. Sung, and Tanabe Seiyaku (100). Worldwide production of biotin in 1994 was approximately 60 metric tons. The Hst price for pure biotin in 1995 was — 7.00/g whereas, the Hst price for technical feed-grade biotin was — 5.50/g. Biotin is used in various pharmaceutical, food, and special dietary products, including multivitamin preparations in Hquid, tablet, capsule, or powder forms. One of the commercially available products of i7-biotin is Britrit-1, which is a 1% biotin trituration used in food premixes. 

A new variant of the three-component, one-pot synthesis of L-foUc acid has been reported by Hoffmann-La Roche Inc. 

U.S. manufacturers of niacin and niacinamide include Nepera, Inc. and Reilly Industries, Inc. U.S. suppliers include BASF Corporation, Hoffmann-La Roche Inc., and Rhc ne-Poulenc. Western European producers and suppHers include Degussa, Rhc ne-Poulenc, BASF, Hoffmann-La Roche, and Lon2a (71). In 1995, the prices for niacin and nicotinamide were 9.75/kg and 9.25/kg, respectively (72,73). 

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